Further, they have identified an existing anti-inflammatory drug that in laboratory tests blocks the death of these cells — and now are planning a Phase 2 clinical trial to determine if this drug or a similar drug can prevent HIV-infected people from developing AIDS.
Two
separate journal articles, published simultaneously in Nature and Science,
detail the research from the laboratory of Dr. Warner C. Greene, who directs
virology and immunology research at Gladstone, an independent
biomedical-research nonprofit.
His
lab’s Science paper reveals how, during an HIV infection, a protein known as
IFI16 senses fragments of HIV DNA in abortively infected immune cells. This
triggers the activation of the human enzyme caspase-1 and leads to pyroptosis,
a fiery and highly inflammatory form of cell death.
As
revealed in Nature, this repetitive cycle of abortive infection, cell death,
inflammation and recruitment of additional CD4 T cells to the infection “hot
zone” ultimately destroys the immune system and causes AIDS.
“Gladstone
has showed how the body’s own immune response to HIV causes CD4 T cell death
via a pathway triggering inflammation, and secondly by identifying the host DNA
sensor that detects the viral DNA and triggers this death response,” said Dr.
Robert F.
Siliciano,
a professor of medicine at Johns Hopkins University, and a Howard Hughes
Medical Institute investigator. “This one-two punch of discoveries underscores
the critical value of basic science — by uncovering the major cause of CD4 T
cell depletion in AIDS, Dr. Greene’s lab has been able to identify a potential
new therapy for blocking the disease’s progression and improving on current antiretroviral
medications.”
Source:Punch
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